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CASP12 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CASP12 Antibody (Center) AP12027C
    CASP12 Antibody (Center) (Cat. #AP12027c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CASP12 antibody detected the CASP12 protein (arrow).
  • IHC-P - CASP12 Antibody (Center) AP12027C
    CASP12 Antibody (Center) (Cat. #AP12027c)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CASP12 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CASP12 Antibody (Center) AP12027C
    CASP12 Antibody (Center) (Cat. #AP12027c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IF - CASP12 Antibody (Center) AP12027C
    Confocal immunofluorescent analysis of CASP12 Antibody (Center)(Cat#AP12027c) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UXS9
Other Accession NP_001177945.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38865 Da
Antigen Region 165-193 aa
Additional Information
Gene ID 100506742
Other Names Inactive caspase-12, CASP-12, CASP12
Target/Specificity This CASP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human CASP12.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCASP12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP12
Function Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Tissue Location Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis
Research Areas
Citations (0)

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Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.


Lee, H.J., et al. Arch. Biochem. Biophys. 502(1):68-73(2010)
Plantinga, T.S., et al. J. Acquir. Immune Defic. Syndr. 55(1):87-94(2010)
McCall, M.B., et al. Eur. Cytokine Netw. 21(2):77-83(2010)
Kachapati, K., et al. Hum. Mutat. 27 (9), 975 (2006) :
Xue, Y., et al. Am. J. Hum. Genet. 78(4):659-670(2006)

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$ 295.00
$ 99.00
Cat# AP12027C
(40 western blots)
Availability: In Stock
Bulk Size
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