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CASP12 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q6UXS9 |
| Other Accession | NP_001177945.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38907 Da |
| Antigen Region | 165-193 aa |
| Gene ID | 100506742 |
|---|---|
| Other Names | Inactive caspase-12, CASP-12, CASP12 |
| Target/Specificity | This CASP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human CASP12. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CASP12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CASP12 |
|---|---|
| Function | May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF (PubMed:15129283). May lack protease activity (Probable). |
| Tissue Location | Widely expressed, with highest levels in lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
References
Lee, H.J., et al. Arch. Biochem. Biophys. 502(1):68-73(2010)
Plantinga, T.S., et al. J. Acquir. Immune Defic. Syndr. 55(1):87-94(2010)
McCall, M.B., et al. Eur. Cytokine Netw. 21(2):77-83(2010)
Kachapati, K., et al. Hum. Mutat. 27 (9), 975 (2006) :
Xue, Y., et al. Am. J. Hum. Genet. 78(4):659-670(2006)
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