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RDH13 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8NBN7 |
| Other Accession | NP_612421.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35932 Da |
| Antigen Region | 166-194 aa |
| Gene ID | 112724 |
|---|---|
| Other Names | Retinol dehydrogenase 13, 111-, RDH13 |
| Target/Specificity | This RDH13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of human RDH13. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RDH13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RDH13 |
|---|---|
| Synonyms | SDR7C3 |
| Function | Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331). |
| Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein. Note=Localized on the outer side of the inner mitochondrial membrane. |
| Tissue Location | Widely expressed (PubMed:18039331). In the retina, detected in the inner segment of the photoreceptor cells. Weak signals are observed in a small population of inner nuclear neurons and the inner plexiform layer (PubMed:12226107). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described.
References
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :
Belyaeva, O.V., et al. FEBS J. 275(1):138-147(2008)
Haeseleer, F., et al. J. Biol. Chem. 277(47):45537-45546(2002)
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