|Application ||WB, FC, E|
|Other Accession||P17074, Q9CZX8, Q32PD5, NP_001013.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||16060 Da|
|Antigen Region||25-54 aa|
|Other Names||40S ribosomal protein S19, RPS19|
|Target/Specificity||This RPS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the Central region of human RPS19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPS19 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for pre-rRNA processing and maturation of 40S ribosomal subunits.|
|Cellular Location||Nucleus. Note=Located more specifically in the nucleoli|
|Tissue Location||Higher level expression is seen in the colon carcinoma tissue than normal colon tissue|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Devlin, E.E., et al. Blood 116(15):2826-2835(2010)
Iadevaia, V., et al. Oncogene 29(40):5490-5499(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nishiura, H., et al. Apoptosis 15(8):966-981(2010)
Schuster, J., et al. Blood Cells Mol. Dis. 45(1):23-28(2010)
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