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DOK3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DOK3 Antibody (C-term) AP12040b
    DOK3 Antibody (C-term) (Cat. #AP12040b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DOK3 antibody detected the DOK3 protein (arrow).
  • IHC-P - DOK3 Antibody (C-term) AP12040b
    DOK3 Antibody (C-term) (Cat. #AP12040b)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DOK3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q7L591
Other Accession NP_079148.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53288 Da
Antigen Region 293-321 aa
Additional Information
Gene ID 79930
Other Names Docking protein 3, Downstream of tyrosine kinase 3, DOK3
Target/Specificity This DOK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human DOK3.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDOK3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK3
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in spleen.
Research Areas
Citations (0)

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Background

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity).

References

Berger, A.H., et al. Nat. Genet. 42(3):216-223(2010)
Senis, Y.A., et al. J. Thromb. Haemost. 7(10):1718-1726(2009)
Honma, M., et al. Genes Cells 11(2):143-151(2006)
Robson, J.D., et al. Mol. Cell. Biol. 24(6):2332-2343(2004)
Favre, C., et al. Genes Immun. 4(1):40-45(2003)

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$ 295.00
$ 99.00
Cat# AP12040b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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