|Application ||WB, IHC-P, E|
|Calculated MW||53288 Da|
|Antigen Region||293-321 aa|
|Other Names||Docking protein 3, Downstream of tyrosine kinase 3, DOK3|
|Target/Specificity||This DOK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human DOK3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DOK3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in spleen.|
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Provided below are standard protocols that you may find useful for product applications.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity).
Berger, A.H., et al. Nat. Genet. 42(3):216-223(2010)
Senis, Y.A., et al. J. Thromb. Haemost. 7(10):1718-1726(2009)
Honma, M., et al. Genes Cells 11(2):143-151(2006)
Robson, J.D., et al. Mol. Cell. Biol. 24(6):2332-2343(2004)
Favre, C., et al. Genes Immun. 4(1):40-45(2003)
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