|Application ||WB, E|
|Calculated MW||38508 Da|
|Antigen Region||305-333 aa|
|Other Names||Chemokine XC receptor 1, G-protein coupled receptor 5, Lymphotactin receptor, XC chemokine receptor 1, XCR1, CCXCR1, GPR5|
|Target/Specificity||This XCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-333 amino acids from the C-terminal region of human XCR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||XCR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Yamazaki, C., et al. Biochem. Biophys. Res. Commun. 397(4):756-761(2010)
Crozat, K., et al. J. Exp. Med. 207(6):1283-1292(2010)
Bachem, A., et al. J. Exp. Med. 207(6):1273-1281(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Luttichau, H.R. Virol. J. 5, 50 (2008) :
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