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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GSR Antibody (C-term)   

GSR Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GSR Antibody (C-term) AP12046b
    GSR Antibody (C-term) (Cat. #AP12046b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the GSR antibody detected the GSR protein (arrow).
  • IHC-P - GSR Antibody (C-term) AP12046b
    GSR Antibody (C-term) (Cat. #AP12046b)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GSR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - GSR Antibody (C-term) AP12046b
    Confocal immunofluorescent analysis of GSR Antibody (C-term)(Cat#AP12046b) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • FC - GSR Antibody (C-term) AP12046b
    GSR Antibody (C-term) (Cat. #AP12046b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00390
Other Accession NP_000628.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 56257 Da
Antigen Region 380-408 aa
Additional Information
Gene ID 2936
Other Names Glutathione reductase, mitochondrial, GR, GRase, GSR, GLUR, GRD1
Target/Specificity This GSR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-408 amino acids from the C-terminal region of human GSR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGSR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSR
Synonyms GLUR, GRD1
Function Maintains high levels of reduced glutathione in the cytosol.
Cellular Location Isoform Mitochondrial: Mitochondrion.
Research Areas
Citations (0)

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This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.


Satoh, N., et al. Biochem. Genet. 48 (9-10), 816-821 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)

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$ 295.00
$ 99.00
Cat# AP12046b
(40 western blots)
Availability: In Stock
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