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SH2D4A Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SH2D4A Antibody (N-term) AP12049A
    SH2D4A Antibody (N-term) (Cat. #AP12049a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SH2D4A antibody detected the SH2D4A protein (arrow).
    detail
  • IHC-P - SH2D4A Antibody (N-term) AP12049A
    SH2D4A Antibody (N-term) (Cat. #AP12049a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SH2D4A Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9H788
Other Accession NP_071354.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52727 Da
Antigen Region 38-67 aa
Additional Information
Gene ID 63898
Other Names SH2 domain-containing protein 4A, Protein SH(2)A, Protein phosphatase 1 regulatory subunit 38, SH2D4A, PPP1R38, SH2A
Target/Specificity This SH2D4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the N-terminal region of human SH2D4A.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSH2D4A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH2D4A
Synonyms PPP1R38, SH2A
Function Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T- cell development and function.
Cellular Location Cytoplasm. Note=Located at podocyte foot processes.
Tissue Location Ubiquitously expressed. Aberrantly expressed in some cancers.
Research Areas
Citations (0)
citation

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Background

SH2D4A inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Li, T., et al. BMB Rep 42(8):516-522(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Lapinski, P.E., et al. J. Immunol. 181(3):2019-2027(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

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$ 182.50
$ 70.00
Cat# AP12049A
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