|Application ||WB, IHC-P, E|
|Calculated MW||52727 Da|
|Antigen Region||38-67 aa|
|Other Names||SH2 domain-containing protein 4A, Protein SH(2)A, Protein phosphatase 1 regulatory subunit 38, SH2D4A, PPP1R38, SH2A|
|Target/Specificity||This SH2D4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the N-terminal region of human SH2D4A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SH2D4A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.|
|Cellular Location||Cytoplasm. Note=Located at podocyte foot processes.|
|Tissue Location||Ubiquitously expressed. Aberrantly expressed in some cancers.|
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Provided below are standard protocols that you may find useful for product applications.
SH2D4A inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Li, T., et al. BMB Rep 42(8):516-522(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Lapinski, P.E., et al. J. Immunol. 181(3):2019-2027(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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