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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TGIF1 Antibody (Center L223)   

TGIF1 Antibody (Center L223)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TGIF1 Antibody (Center L223) AP12061c
    Western blot analysis of TGIF1 (arrow) using rabbit polyclonal TGIF1 Antibody (Center L223) (Cat. #AP12061c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TGIF1 gene.
  • WB - TGIF1 Antibody (Center L223) AP12061c
    TGIF1 Antibody (Center L223) (Cat. #AP12061c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the TGIF1 antibody detected the TGIF1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15583
Other Accession Q8C0Y1, Q9GZN2, P70284, Q90655, NP_003235.1, NP_733796.2
Reactivity Human, Mouse
Predicted Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43013 Da
Antigen Region 208-237 aa
Additional Information
Gene ID 7050
Other Names Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Target/Specificity This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TGIF1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGIF1 Antibody (Center L223) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGIF1
Synonyms TGIF
Function Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.


Bengoechea-Alonso, M.T., et al. Oncogene 29(38):5322-5328(2010)
Paulussen, A.D., et al. Eur. J. Hum. Genet. 18(9):999-1005(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Demange, C., et al. Mol. Cell 36(6):1073-1085(2009)
Hamid, R., et al. Mol Oncol 3 (5-6), 451-463 (2009) :

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Cat# AP12061c
(40 western blots)
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