|Application ||WB, E|
|Calculated MW||75901 Da|
|Antigen Region||263-292 aa|
|Other Names||TCDD-inducible poly [ADP-ribose] polymerase, ADP-ribosyltransferase diphtheria toxin-like 14, ARTD14, Tiparp|
|Target/Specificity||This Tiparp antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human Tiparp.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Tiparp Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Tiparp is a poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.
Schmahl, J., et al. Genes Dev. 22(23):3255-3267(2008)
Schmahl, J., et al. Nat. Genet. 39(1):52-60(2007)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
Ma, Q. Arch. Biochem. Biophys. 404(2):309-316(2002)
Ma, Q., et al. Biochem. Biophys. Res. Commun. 289(2):499-506(2001)
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