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Tiparp Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Tiparp Antibody (C-term) AP12065b
    Anti-Tiparp Antibody (C-term) at 1:500 dilution + mouse kidney lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 76 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • WB - Tiparp Antibody (C-term) AP12065b
    Tiparp Antibody (C-term) (Cat. #AP12065b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the Tiparp antibody detected the Tiparp protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8C1B2
Other Accession NP_849223.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 75901 Da
Antigen Region 263-292 aa
Additional Information
Gene ID 99929
Other Names TCDD-inducible poly [ADP-ribose] polymerase, ADP-ribosyltransferase diphtheria toxin-like 14, ARTD14, Tiparp
Target/Specificity This Tiparp antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human Tiparp.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTiparp Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tiparp {ECO:0000303|PubMed:11716501, ECO:0000312|MGI:MGI:2159210}
Function ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP- ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)
citation

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Background

Tiparp is a poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.

References

Schmahl, J., et al. Genes Dev. 22(23):3255-3267(2008)
Schmahl, J., et al. Nat. Genet. 39(1):52-60(2007)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
Ma, Q. Arch. Biochem. Biophys. 404(2):309-316(2002)
Ma, Q., et al. Biochem. Biophys. Res. Commun. 289(2):499-506(2001)

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$ 365.00
$ 140.00
Cat# AP12065b
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