Tiparp Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8C1B2 |
Other Accession | NP_849223.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 75901 Da |
Antigen Region | 263-292 aa |
Gene ID | 99929 |
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Other Names | TCDD-inducible poly [ADP-ribose] polymerase, ADP-ribosyltransferase diphtheria toxin-like 14, ARTD14, Tiparp |
Target/Specificity | This Tiparp antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human Tiparp. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Tiparp Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Tiparp {ECO:0000303|PubMed:11716501, ECO:0000312|MGI:MGI:2159210} |
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Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP- ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable). |
Cellular Location | Nucleus. |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tiparp is a poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.
References
Schmahl, J., et al. Genes Dev. 22(23):3255-3267(2008)
Schmahl, J., et al. Nat. Genet. 39(1):52-60(2007)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
Ma, Q. Arch. Biochem. Biophys. 404(2):309-316(2002)
Ma, Q., et al. Biochem. Biophys. Res. Commun. 289(2):499-506(2001)
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