|Application ||WB, FC, E|
|Other Accession||NP_060105.3, NP_057112.3|
|Calculated MW||99187 Da|
|Antigen Region||4-20 aa|
|Other Names||Histone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, SUV420H1, KMT5B|
|Target/Specificity||This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 759-789 amino acids from the C-terminal region of human SUV4-20H1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SUV4-20H1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.|
|Cellular Location||Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.
Chinenov, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 105(51):20185-20190(2008)
Yang, H., et al. J. Biol. Chem. 283(18):12085-12092(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Tryndyak, V.P., et al. Cancer Biol. Ther. 5(1):65-70(2006)
Twells, R.C., et al. Genomics 72(3):231-242(2001)
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