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SUV4-20H1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12072b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12072b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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SUV4-20H1 Antibody (C-term) - Product info | |
| Application | WB, FC
|
| Primary Accession | Q4FZB7 |
| Other Accession | NP_060105.3, NP_057112.3 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 99187 Da |
SUV4-20H1 Antibody (C-term) - Additional info | |
| Gene ID 51111 | |
| Other Names SUV420H1; KMT5B; Histone-lysine N-methyltransferase SUV420H1; Lysine N-methyltransferase 5B; Suppressor of variegation 4-20 homolog 1 | |
| Target/Specificity This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 766-797 amino acids from the C-terminal region of human SUV4-20H1. | |
| Dilution WB~~1:100~500WB~~1:1000 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SUV4-20H1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SUV4-20H1 Antibody (C-term) - Protein Information | |
| Name SUV420H1 | |
| Synonyms KMT5B | |
| Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity) | |
| Cellular Location Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity) | |
SUV4-20H1 Antibody (C-term) - Related products
SUV4-20H1 Antibody (C-term) - Application data
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SUV4-20H1 Antibody (C-term) (Cat. #AP12072b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SUV4-20H1 antibody detected the SUV4-20H1 protein (arrow).
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SUV4-20H1 Antibody (C-term) (Cat. #AP12072b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
SUV4-20H1 Antibody (C-term) - Research Areas
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BACKGROUND
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.
REFERENCES
Chinenov, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 105(51):20185-20190(2008) Yang, H., et al. J. Biol. Chem. 283(18):12085-12092(2008) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : Tryndyak, V.P., et al. Cancer Biol. Ther. 5(1):65-70(2006) Twells, R.C., et al. Genomics 72(3):231-242(2001)
