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SUV4-20H1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q4FZB7 |
| Other Accession | NP_060105.3, NP_057112.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 99188 Da |
| Antigen Region | 4-20 aa |
| Gene ID | 51111 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, SUV420H1, KMT5B |
| Target/Specificity | This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 759-789 amino acids from the C-terminal region of human SUV4-20H1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SUV4-20H1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KMT5B (HGNC:24283) |
|---|---|
| Synonyms | SUV420H1 |
| Function | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys- 20' of histone H4 (By similarity). |
| Cellular Location | Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.
References
Chinenov, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 105(51):20185-20190(2008)
Yang, H., et al. J. Biol. Chem. 283(18):12085-12092(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Tryndyak, V.P., et al. Cancer Biol. Ther. 5(1):65-70(2006)
Twells, R.C., et al. Genomics 72(3):231-242(2001)
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