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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SUV4-20H1 Antibody (C-term)   

SUV4-20H1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SUV4-20H1 Antibody (C-term) AP12072b
    Western blot analysis of lysates from HT-29, PC-3 cell line (from left to right), using SUV4-20H1 Antibody (C-term)(Cat. #AP12072B). AP12072B was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • WB - SUV4-20H1 Antibody (C-term) AP12072b
    SUV4-20H1 Antibody (C-term) (Cat. #AP12072b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SUV4-20H1 antibody detected the SUV4-20H1 protein (arrow).
  • FC - SUV4-20H1 Antibody (C-term) AP12072b
    SUV4-20H1 Antibody (C-term) (Cat. #AP12072b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q4FZB7
Other Accession NP_060105.3, NP_057112.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 99187 Da
Antigen Region 4-20 aa
Additional Information
Gene ID 51111
Other Names Histone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, SUV420H1, KMT5B
Target/Specificity This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 759-789 amino acids from the C-terminal region of human SUV4-20H1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSUV4-20H1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SUV420H1
Synonyms KMT5B
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.
Cellular Location Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Research Areas
Citations (0)

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This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.


Chinenov, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 105(51):20185-20190(2008)
Yang, H., et al. J. Biol. Chem. 283(18):12085-12092(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Tryndyak, V.P., et al. Cancer Biol. Ther. 5(1):65-70(2006)
Twells, R.C., et al. Genomics 72(3):231-242(2001)

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Cat# AP12072b
(40 western blots)

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