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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   PCAF Antibody (N-term)   

PCAF Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PCAF Antibody (N-term) AP12074a
    PCAF Antibody (N-term) (Cat. #AP12074a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PCAF antibody detected the PCAF protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92831
Other Accession Q9JHD1, NP_003875.3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 93013 Da
Antigen Region 253-283 aa
Additional Information
Gene ID 8850
Other Names Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, P300/CBP-associated factor, P/CAF, KAT2B, PCAF
Target/Specificity This PCAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-283 amino acids from the N-terminal region of human PCAF.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPCAF Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT2B
Synonyms PCAF
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed but most abundant in heart and skeletal muscle.
Research Areas
Citations (0)

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CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.


Perez, R.E., et al. J. Cell. Physiol. 225(2):394-405(2010)
Mooney, S.M., et al. J. Biol. Chem. 285(40):30443-30452(2010)
Aoyama, T., et al. J. Biol. Chem. 285(39):29842-29850(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Shimahara, A., et al. J. Biol. Chem. 285(22):16967-16977(2010)

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$ 295.00
$ 99.00
Cat# AP12074a
(40 western blots)
Availability: In Stock
Bulk Size
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