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CYP5A1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CYP5A1 Antibody (Center) AP12077c
    CYP5A1 Antibody (Center) (Cat. #AP12077c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CYP5A1 antibody detected the CYP5A1 protein (arrow).
  • IHC-P - CYP5A1 Antibody (Center) AP12077c
    CYP5A1 Antibody (Center) (Cat. #AP12077c)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYP5A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24557
Other Accession Q2PG45, Q2KIG5, NP_001052.2, NP_001124438.1
Reactivity Mouse
Predicted Bovine, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60518 Da
Antigen Region 226-257 aa
Additional Information
Gene ID 6916
Other Names Thromboxane-A synthase, TXA synthase, TXS, Cytochrome P450 5A1, TBXAS1, CYP5, CYP5A1
Target/Specificity This CYP5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-257 amino acids from the Central region of human CYP5A1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYP5A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CYP5, CYP5A1
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Platelets, lung, kidney, spleen, macrophages and lung fibroblasts
Research Areas
Citations (0)

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Wang, L.H., et al. Prostaglandins Other Lipid Mediat. 68-69, 409-422 (2002) :
Tazawa, R., et al. Arch. Biochem. Biophys. 334(2):349-356(1996)
Baek, S.J., et al. Gene 173(2):251-256(1996)
Wang, L.H., et al. Arch. Biochem. Biophys. 315(2):273-278(1994)

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Cat# AP12077c
(40 western blots)
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