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CFD Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - CFD Antibody (N-term) AP12089a
    Anti-CFD Antibody (N-term) at 1:2000 dilution + human plasma lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CFD Antibody (N-term) AP12089a
    Anti-CFD Antibody (N-term) at 1:2000 dilution + human plasma lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CFD Antibody (N-term) AP12089a
    Anti-CFD Antibody (N-term) at 1:2000 dilution + human plasma lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CFD Antibody (N-term) AP12089a
    Anti-CFD Antibody (N-term)at 1:2000 dilution + human plasma lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CFD Antibody (N-term) AP12089a
    Anti-CFD Antibody (N-term)at 1:2000 dilution + human plasma lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CFD Antibody (N-term) AP12089a
    Anti-CFD Antibody (N-term)at 1:2000 dilution + human plasma lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CFD Antibody (N-term) AP12089a
    Western blot analysis of lysate from human plasma tissue lysate, using CFD Antibody (N-term)(Cat. #AP12089a). AP12089a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
  • WB - CFD Antibody (N-term) AP12089a
    CFD Antibody (N-term) (Cat. #AP12089a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CFD antibody detected the CFD protein (arrow).
  • IHC-P - CFD Antibody (N-term) AP12089a
    CFD Antibody (N-term) (Cat. #AP12089a)immunohistochemistry analysis in formalin fixed and paraffin embedded human bladder carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CFD Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P00746
Other Accession P51779, Q3T0A3, NP_001919.2
Reactivity Human
Predicted Bovine, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27033 Da
Antigen Region 68-99 aa
Additional Information
Gene ID 1675
Other Names Complement factor D, Adipsin, C3 convertase activator, Properdin factor D, CFD, DF, PFD
Target/Specificity This CFD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-99 amino acids from the N-terminal region of human CFD.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCFD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFD
Synonyms DF, PFD
Function Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :
Hietaharju, A., et al. Eur. J. Neurol. 17(2):332-334(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Ciprandi, G., et al. Int. Immunopharmacol. 9(12):1460-1463(2009)
Cerhan, J.R., et al. Br. J. Haematol. 145(5):614-623(2009)

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$ 295.00
$ 99.00
Cat# AP12089a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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