|Application ||WB, IHC-P, E|
|Other Accession||P51779, Q3T0A3, NP_001919.2|
|Calculated MW||27033 Da|
|Antigen Region||68-99 aa|
|Other Names||Complement factor D, Adipsin, C3 convertase activator, Properdin factor D, CFD, DF, PFD|
|Target/Specificity||This CFD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-99 amino acids from the N-terminal region of human CFD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CFD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Hietaharju, A., et al. Eur. J. Neurol. 17(2):332-334(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Ciprandi, G., et al. Int. Immunopharmacol. 9(12):1460-1463(2009)
Cerhan, J.R., et al. Br. J. Haematol. 145(5):614-623(2009)
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