|Application ||WB, IHC-P, FC, E|
|Calculated MW||50344 Da|
|Antigen Region||321-348 aa|
|Other Names||Zinc finger MYND domain-containing protein 10, Protein BLu, ZMYND10, BLU|
|Target/Specificity||This ZMYND10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-348 amino acids from the Central region of human ZMYND10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZMYND10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to sites proximal to the axoneme.|
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Provided below are standard protocols that you may find useful for product applications.
BLU is a candidate tumor suppressor gene, that spans 4.5 kb on 3p21.3. It encodes a 50 kd protein, which is commonly found in transcription repressors. It is suspected that BLU has a function in cell cycle progression. BLU is a stress-responsive gene regulated by E2F.12 It is commonly found to be downregulated in non-small cell lung cancer, esophagus squamous cell carcinoma and nasopharyngeal carcinoma (NPC).
Shao, Y., et al. Cancer Invest. 28(6):642-648(2010)
Lorente, A., et al. Brain Pathol. 19(2):279-292(2009)
Muzny, D.M., et al. Nature 440(7088):1194-1198(2006)
Marsit, C.J., et al. Int. J. Cancer 114(2):219-223(2005)
Qiu, G.H., et al. Oncogene 23(27):4793-4806(2004)
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