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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TXNL2 Antibody (N-term)   

TXNL2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TXNL2 Antibody (N-term) AP12099a
    All lanes : Anti-TXNL2 Antibody (N-term) at 1:1000 dilution Lane 1: HepG2 whole cell lysate Lane 2: Raji whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 37 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - TXNL2 Antibody (N-term) AP12099a
    TXNL2 Antibody (N-term) (Cat. #AP12099a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TXNL2 antibody detected the TXNL2 protein (arrow).
  • WB - TXNL2 Antibody (N-term) AP12099a
    TXNL2 Antibody (N-term) (Cat. #AP12099a) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the TXNL2 antibody detected the TXNL2 protein (arrow).
  • FC - TXNL2 Antibody (N-term) AP12099a
    TXNL2 Antibody (N-term) (Cat. #AP12099a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession O76003
Other Accession Q58DA7, NP_006532.2
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37432 Da
Antigen Region 81-110 aa
Additional Information
Gene ID 10539
Other Names Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2, GLRX3, PICOT, TXNL2
Target/Specificity This TXNL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human TXNL2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTXNL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLRX3
Synonyms PICOT, TXNL2
Function Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Cellular Location Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity).
Tissue Location Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine
Research Areas
Citations (0)

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Background

GLRX3 is a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

References

Ohayon, A., et al. J. Histochem. Cytochem. 58(9):799-806(2010)
Haunhorst, P., et al. Biochem. Biophys. Res. Commun. 394(2):372-376(2010)
Ohayon, A., et al. J Immunotoxicol 7(1):8-14(2010)
Cha, M.K., et al. Cancer Epidemiol 33 (3-4), 281-287 (2009) :
Roeske, D., et al. Mol. Psychiatry (2009) In press :

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$ 295.00
$ 99.00
Cat# AP12099a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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