|Application ||WB, FC, E|
|Other Accession||Q58DA7, NP_006532.2|
|Calculated MW||37432 Da|
|Antigen Region||81-110 aa|
|Other Names||Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2, GLRX3, PICOT, TXNL2|
|Target/Specificity||This TXNL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human TXNL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TXNL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.|
|Cellular Location||Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity).|
|Tissue Location||Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
GLRX3 is a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Ohayon, A., et al. J. Histochem. Cytochem. 58(9):799-806(2010)
Haunhorst, P., et al. Biochem. Biophys. Res. Commun. 394(2):372-376(2010)
Ohayon, A., et al. J Immunotoxicol 7(1):8-14(2010)
Cha, M.K., et al. Cancer Epidemiol 33 (3-4), 281-287 (2009) :
Roeske, D., et al. Mol. Psychiatry (2009) In press :
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