|Application ||WB, IHC-P, E|
|Other Accession||Q9Z0V5, O08807, Q9BGI2, NP_006397.1|
|Calculated MW||30540 Da|
|Antigen Region||82-110 aa|
|Other Names||Peroxiredoxin-4, Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372, PRDX4|
|Target/Specificity||This PRDX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the Central region of human PRDX4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRDX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I- kappa-B-alpha phosphorylation.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.
Jamaluddin, M., et al. J. Virol. 84(18):9533-9545(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Edvardsen, H., et al. Pharmacogenomics J. (2010) In press :
Wang, H.Q., et al. FEBS Lett. 583(9):1511-1515(2009)
Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)
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