|Application ||WB, IHC-P, E|
|Other Accession||Q5BK82, NP_542783.2, NP_892030.3|
|Calculated MW||57419 Da|
|Antigen Region||101-129 aa|
|Other Names||E3 ubiquitin-protein ligase TRIM69, 632-, RFP-like domain-containing protein trimless, RING finger protein 36, Tripartite motif-containing protein 69, TRIM69, RNF36|
|Target/Specificity||This TRIM69 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-129 amino acids from the N-terminal region of human TRIM69.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM69 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus speckle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. It may play a role in apoptosis (By similarity).
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Shyu, H.W., et al. Exp. Cell Res. 287(2):301-313(2003)
Shyu, H.W., et al. Mech. Dev. 108 (1-2), 213-216 (2001) :
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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