|Application ||WB, E|
|Calculated MW||25394 Da|
|Antigen Region||99-128 aa|
|Other Names||Putative claudin-25, CLDN25|
|Target/Specificity||This hCG_1646420 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-128 amino acids from the Central region of human hCG_1646420.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||hCG_1646420 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.
Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
Krause, G., et al. Biochim. Biophys. Acta 1778(3):631-645(2008)
Katoh, M., et al. Int. J. Mol. Med. 11(6):683-689(2003)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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