|Application ||WB, IF, E|
|Calculated MW||21013 Da|
|Antigen Region||117-145 aa|
|Other Names||Cytochrome b-245 light chain, Cytochrome b(558) alpha chain, Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, p22 phagocyte B-cytochrome, p22-phox, p22phox, CYBA|
|Target/Specificity||This CYBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-145 amino acids from the C-terminal region of human CYBA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYBA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|
|Cellular Location||Cell membrane|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Katakami, N., et al. Atherosclerosis 212(2):534-538(2010)
Tu, Y.C., et al. Acta Pharmacol. Sin. 31(7):874-880(2010)
Moreno, M.U., et al. Drug News Perspect. 23(5):316-324(2010)
Cross, D.S., et al. BMC Genet. 11, 51 (2010) :
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