|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||50055 Da|
|Antigen Region||366-393 aa|
|Other Names||Protein naked cuticle homolog 2, Naked-2, hNkd2, NKD2|
|Target/Specificity||This NKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-393 amino acids from the C-terminal region of human NKD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.|
|Cellular Location||Cell membrane. Cytoplasm. Cytoplasmic vesicle|
|Tissue Location||Expressed in kidney, lung, pancreas and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)
Ding, W., et al. Proc. Natl. Acad. Sci. U.S.A. 105(36):13433-13438(2008)
Li, C., et al. Mol. Biol. Cell 18(8):3081-3093(2007)
Adamowicz, M., et al. Genes Chromosomes Cancer 45(9):829-838(2006)
Li, C., et al. Proc. Natl. Acad. Sci. U.S.A. 101(15):5571-5576(2004)
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