|Application ||WB, IHC-P, E|
|Other Accession||Q8BLG0, NP_057520.2|
|Calculated MW||115386 Da|
|Antigen Region||123-151 aa|
|Other Names||PHD finger protein 20, Glioma-expressed antigen 2, Hepatocellular carcinoma-associated antigen 58, Novel zinc finger protein, Transcription factor TZP, PHF20, C20orf104, GLEA2, HCA58, NZF, TZP|
|Target/Specificity||This PHF20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-151 amino acids from the N-terminal region of human PHF20.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHF20 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C20orf104, GLEA2, HCA58, NZF, TZP|
|Function||Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.|
|Tissue Location||Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
PHF20 is possible a transcription factor.
Bankovic, J., et al. Lung Cancer 67(2):151-159(2010)
Heisel, S.M., et al. PLoS ONE 3 (5), E2164 (2008) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Pallasch, C.P., et al. Int. J. Cancer 117(3):456-459(2005)
Dou, Y., et al. Cell 121(6):873-885(2005)
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