|Application ||WB, IHC-P, FC, E|
|Other Accession||Q3UVR3, NP_775771.3|
|Calculated MW||137412 Da|
|Antigen Region||217-245 aa|
|Other Names||Tau-tubulin kinase 2, TTBK2, KIAA0847|
|Target/Specificity||This TTBK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the N-terminal region of human TTBK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TTBK2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.|
|Cellular Location||Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xu, Q., et al. Neurol. Sci. 31(1):107-109(2010)
Edener, U., et al. J. Neurol. 256(11):1856-1859(2009)
Houlden, H., et al. Nat. Genet. 39(12):1434-1436(2007)
Kitano-Takahashi, M., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (PT 7), 602-604 (2007) :
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