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TAF4B Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TAF4B Antibody (C-term) AP12163B
    Anti-TAF4B Antibody (C-term) at 1:1000 dilution + Ramos whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 91 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • FC - TAF4B Antibody (C-term) AP12163B
    TAF4B Antibody (C-term) (Cat. #AP12163b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q92750
Other Accession G5E8Z2, NP_005631.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 91091 Da
Antigen Region 647-675 aa
Additional Information
Gene ID 6875
Other Names Transcription initiation factor TFIID subunit 4B, Transcription initiation factor TFIID 105 kDa subunit, TAF(II)105, TAFII-105, TAFII105, TAF4B, TAF2C2, TAFII105
Target/Specificity This TAF4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-675 amino acids from the C-terminal region of human TAF4B.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTAF4B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAF4B
Synonyms TAF2C2, TAFII105
Function Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Cellular Location Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation
Tissue Location Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells
Citations (0)

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Background

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).

References

Kalogeropoulou, M., et al. Mol. Cancer Res. 8(4):554-568(2010)
Gazit, K., et al. J. Biol. Chem. 284(39):26286-26296(2009)
Knauff, E.A., et al. Hum. Reprod. 24(9):2372-2378(2009)
Teye, K., et al. Int. J. Oncol. 33(6):1271-1280(2008)
Liu, W.L., et al. Mol. Cell 29(1):81-91(2008)

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$ 295.00
$ 99.00
Cat# AP12163B
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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