|Application ||WB, FC, E|
|Other Accession||G5E8Z2, NP_005631.1|
|Calculated MW||91091 Da|
|Antigen Region||647-675 aa|
|Other Names||Transcription initiation factor TFIID subunit 4B, Transcription initiation factor TFIID 105 kDa subunit, TAF(II)105, TAFII-105, TAFII105, TAF4B, TAF2C2, TAFII105|
|Target/Specificity||This TAF4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-675 amino acids from the C-terminal region of human TAF4B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAF4B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.|
|Cellular Location||Nucleus. Cytoplasm Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation|
|Tissue Location||Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).
Kalogeropoulou, M., et al. Mol. Cancer Res. 8(4):554-568(2010)
Gazit, K., et al. J. Biol. Chem. 284(39):26286-26296(2009)
Knauff, E.A., et al. Hum. Reprod. 24(9):2372-2378(2009)
Teye, K., et al. Int. J. Oncol. 33(6):1271-1280(2008)
Liu, W.L., et al. Mol. Cell 29(1):81-91(2008)
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