|Application ||WB, IHC-P, E|
|Other Accession||NP_653272.2, NP_001171468.1|
|Calculated MW||27215 Da|
|Antigen Region||3-31 aa|
|Other Names||Sesquipedalian-1, Ses1, 27 kDa inositol polyphosphate phosphatase-interacting protein A, IPIP27A, FAM109A|
|Target/Specificity||This FAM109A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-31 amino acids from the N-terminal region of human FAM109A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAM109A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|
|Cellular Location||Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin- coated vesicle. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants.
Swan, L.E., et al. Proc. Natl. Acad. Sci. U.S.A. 107(8):3511-3516(2010)
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