|Application ||WB, IHC-P, E|
|Other Accession||Q5UE96, NP_002236.1|
|Calculated MW||38143 Da|
|Antigen Region||293-320 aa|
|Other Names||Potassium channel subfamily K member 1, Inward rectifying potassium channel protein TWIK-1, Potassium channel KCNO1, KCNK1, HOHO1, KCNO1, TWIK1|
|Target/Specificity||This KCNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the C-terminal region of human KCNK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HOHO1, KCNO1, TWIK1|
|Function||Weakly inward rectifying potassium channel that contributes to the regulation of the resting membrane potential.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney (PubMed:8605869).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.
Feliciangeli, S., et al. J. Biol. Chem. 285(7):4798-4805(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Zhou, M., et al. J. Neurosci. 29(26):8551-8564(2009)
Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)
Rajan, S., et al. Cell 121(1):37-47(2005)
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