|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||32866 Da|
|Antigen Region||128-155 aa|
|Other Names||ADP/ATP translocase 3, ADP, ATP carrier protein 3, ADP, ATP carrier protein, isoform T2, ANT 2, Adenine nucleotide translocator 3, ANT 3, Solute carrier family 25 member 6, ADP/ATP translocase 3, N-terminally processed, SLC25A6, ANT3|
|Target/Specificity||This SLC25A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-155 amino acids from the Central region of human SLC25A6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC25A6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene.
Danishuddin, M., et al. J Mol Model 16(3):535-541(2010)
Hu, Z., et al. FEBS Lett. 583(2):383-388(2009)
Yang, Z., et al. Mol. Biol. Cell 18(11):4681-4689(2007)
Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
Jang, J.Y., et al. Cell. Immunol. 241(1):14-25(2006)
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