|Application ||WB, FC, E|
|Calculated MW||24894 Da|
|Antigen Region||9-36 aa|
|Other Names||High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1, HMG1|
|Target/Specificity||This HMG1L10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-36 amino acids from the N-terminal region of human HMG1L10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HMG1L10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
HMGB1L10 binds preferentially single-stranded DNA and unwinds double stranded DNA (By similarity).
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