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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   Mouse Parp9 Antibody (N-term)   

Mouse Parp9 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Parp9 Antibody (N-term) AP12195a
    Parp9 Antibody (N-term) (Cat. #AP12195a) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Parp9 antibody detected the Parp9 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8CAS9
Other Accession NP_084529
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 96659 Da
Antigen Region 441-470 aa
Additional Information
Gene ID 80285
Other Names Poly [ADP-ribose] polymerase 9, PARP-9, ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein homolog, Parp9, Bal
Target/Specificity This Mouse Parp9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from the N-terminal region of mouse Parp9.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Parp9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Parp9
Synonyms Bal
Function ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP- ribose) (By similarity). In addition, positively regulates DTXL3 protein levels (By similarity). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP- ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (By similarity). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (By similarity). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). In response to DNA damage, PARP9-DTX3L complex is required for efficient non- homologous end joining (NHEJ) but the complex function is restrained by PARP9 activity (By similarity). Dispensable for B- cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (PubMed:28105679). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP- ribosylation (By similarity).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8IXQ6}. Nucleus {ECO:0000250|UniProtKB:Q8IXQ6}. Note=Shuttles between the nucleus and the cytosol. Translocates to the nucleus in response to IFNG or IFNB1 stimulation. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner. {ECO:0000250|UniProtKB:Q8IXQ6}
Tissue Location Highly expressed in the thymus and intestine (PubMed:18069692). Expressed in macrophages (PubMed:27796300)
Research Areas
Citations (0)

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Background

PARP9 is a novel risk related gene that is expressed at higher levels in fatal high risk diffuse large B cell lymphomas.

References

Hakme, A., et al. Dev. Dyn. 237(1):209-215(2008)

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Cat# AP12195a
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(40 western blots)
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