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>   home   >   Products   >   Primary Antibodies   >   hGCN5 Antibody (C-term)   

hGCN5 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - hGCN5 Antibody (C-term) AP12198b
    hGCN5 Antibody (C-term) (Cat. #AP12198b) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the hGCN5 antibody detected the hGCN5 protein (arrow).
  • FC - hGCN5 Antibody (C-term) AP12198b
    hGCN5 Antibody (C-term) (Cat. #AP12198b) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92830
Other Accession Q9JHD2, NP_066564
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 93926 Da
Antigen Region 807-837 aa
Additional Information
Gene ID 2648
Other Names Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5
Target/Specificity This hGCN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 807-837 amino acids from the C-terminal region of human hGCN5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionshGCN5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT2A
Synonyms GCN5, GCN5L2, HGCN5
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Cellular Location Nucleus.
Tissue Location Expressed in all tissues tested, with most abundant expression in ovary
Citations (0)

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KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).


Terreni, M., et al. Retrovirology 7, 18 (2010) :
Atanassov, B.S., et al. Mol. Cell 35(3):352-364(2009)
Kelly, T.J., et al. J. Biol. Chem. 284(30):19945-19952(2009)
Mao, X., et al. Genes Dev. 23(7):849-861(2009)
Paolinelli, R., et al. Nat. Struct. Mol. Biol. 16(4):412-420(2009)

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Cat# AP12198b
(40 western blots)
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