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>   home   >   Products   >   Primary Antibodies   >   MAFB Antibody (C-term)   

MAFB Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAFB Antibody (C-term) AP12233B
    MAFB Antibody (C-term) (Cat. #AP12233b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MAFB antibody detected the MAFB protein (arrow).
  • FC - MAFB Antibody (C-term) AP12233B
    MAFB Antibody (C-term) (Cat. #AP12233b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y5Q3
Other Accession Q6DE84, P54842, P54841, Q2PFS4, NP_005452.2
Reactivity Human
Predicted Monkey, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35792 Da
Antigen Region 266-292 aa
Additional Information
Gene ID 9935
Other Names Transcription factor MafB, Maf-B, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, MAFB, KRML
Target/Specificity This MAFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-292 amino acids from the C-terminal region of human MAFB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAFB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KRML
Function Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}
Tissue Location Ubiquitous..
Citations (0)

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The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq].


Kim, H., et al. Nat. Immunol. 11(8):743-750(2010)
Beaty, T.H., et al. Nat. Genet. 42(6):525-529(2010)
Vatsveen, T.K., et al. Leuk. Res. 33(12):1670-1677(2009)
Zanocco-Marani, T., et al. Exp. Cell Res. 315(11):1798-1808(2009)
Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009)

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Cat# AP12233B
(40 western blots)
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