|Application ||WB, E|
|Other Accession||Q3V1L4, O46411, NP_036361.1|
|Calculated MW||64970 Da|
|Antigen Region||5-33 aa|
|Other Names||Cytosolic purine 5'-nucleotidase, Cytosolic 5'-nucleotidase II, NT5C2, NT5B, NT5CP, PNT5|
|Target/Specificity||This NT5C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human NT5C2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NT5C2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NT5B, NT5CP, PNT5|
|Function||May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.|
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Provided below are standard protocols that you may find useful for product applications.
Purine 5-prime-nucleotidase (EC 22.214.171.124) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides, and is allosterically activated by various compounds, including ATP. The enzyme is exclusively located in the cytoplasmic matrix of cells and may have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases.[supplied by OMIM].
Niu, W., et al. Clin. Chim. Acta 411 (19-20), 1491-1495 (2010) :
Yamauchi, T., et al. Biochem. Pharmacol. 77(12):1780-1786(2009)
Newton-Cheh, C., et al. Nat. Genet. (2009) In press :
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Jordheim, L.P., et al. Drug Metab. Dispos. 36(12):2419-2423(2008)
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