|Application ||WB, IHC-P, E|
|Other Accession||Q9EQQ4, NP_009158.3|
|Calculated MW||41967 Da|
|Antigen Region||121-149 aa|
|Other Names||Probable G-protein coupled receptor 45, PSP24-1, PSP24-alpha, GPR45|
|Target/Specificity||This GPR45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-149 amino acids from the Central region of human GPR45.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR45 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor. May play a role in brain function.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.
Salonen, J.T., et al. Am. J. Hum. Genet. 81(2):338-345(2007) Wu, C., et al. Proteomics 7(11):1775-1785(2007) Hillier, L.W., et al. Nature 434(7034):724-731(2005) Kawasawa, Y., et al. Biochem. Biophys. Res. Commun. 276(3):957-964(2000) Kawasawa, Y., et al. Biochem. Biophys. Res. Commun. 276(3):952-956(2000)
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