|Application ||WB, IHC-P, FC, E|
|Calculated MW||112935 Da|
|Antigen Region||964-994 aa|
|Other Names||Enteropeptidase, Enterokinase, Serine protease 7, Transmembrane protease serine 15, Enteropeptidase non-catalytic heavy chain, Enteropeptidase catalytic light chain, TMPRSS15, ENTK, PRSS7|
|Target/Specificity||This PRSS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 964-994 amino acids from the C-terminal region of human PRSS7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRSS7 Antibody (C-term E979) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Intestinal brush border.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nakanishi, J., et al. J. Invest. Dermatol. 130(4):944-952(2010)
Vilen, S.T., et al. Exp. Cell Res. 314(4):914-926(2008)
Imamura, T., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (6), G1235-G1241 (2003) :
Holzinger, A., et al. Am. J. Hum. Genet. 70(1):20-25(2002)
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