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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PRSS7 Antibody (C-term E979)   

PRSS7 Antibody (C-term E979)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PRSS7 Antibody (C-term E979) AP12255b
    Anti-PRSS7 Antibody (E979) at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 113 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - PRSS7 Antibody (C-term E979) AP12255b
    PRSS7 Antibody (C-term E979) (Cat. #AP12255b)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PRSS7 Antibody (C-term E979) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - PRSS7 Antibody (C-term E979) AP12255b
    PRSS7 Antibody (C-term E979) (Cat. #AP12255b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession P98073
Other Accession NP_002763.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 112935 Da
Antigen Region 964-994 aa
Additional Information
Gene ID 5651
Other Names Enteropeptidase, Enterokinase, Serine protease 7, Transmembrane protease serine 15, Enteropeptidase non-catalytic heavy chain, Enteropeptidase catalytic light chain, TMPRSS15, ENTK, PRSS7
Target/Specificity This PRSS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 964-994 amino acids from the C-terminal region of human PRSS7.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRSS7 Antibody (C-term E979) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMPRSS15
Synonyms ENTK, PRSS7
Function Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Intestinal brush border.
Research Areas
Citations (0)

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Background

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nakanishi, J., et al. J. Invest. Dermatol. 130(4):944-952(2010)
Vilen, S.T., et al. Exp. Cell Res. 314(4):914-926(2008)
Imamura, T., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (6), G1235-G1241 (2003) :
Holzinger, A., et al. Am. J. Hum. Genet. 70(1):20-25(2002)

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$ 295.00
$ 99.00
Cat# AP12255b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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