|Application ||WB, E|
|Other Accession||Q6P4S8, NP_001073922.2|
|Calculated MW||244297 Da|
|Antigen Region||113-142 aa|
|Other Names||Integrator complex subunit 1, Int1, INTS1, KIAA1440|
|Target/Specificity||This INTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-142 amino acids from the N-terminal region of human INTS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INTS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.|
|Cellular Location||Nucleus membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).
Nusbaum, C., et al. Nature 439(7074):331-335(2006)
Baillat, D., et al. Cell 123(2):265-276(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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