INTS1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8N201 |
Other Accession | Q6P4S8, NP_001073922.2 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 244297 Da |
Antigen Region | 113-142 aa |
Gene ID | 26173 |
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Other Names | Integrator complex subunit 1, Int1, INTS1, KIAA1440 |
Target/Specificity | This INTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-142 amino acids from the N-terminal region of human INTS1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | INTS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INTS1 |
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Synonyms | KIAA1440 |
Function | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). |
Cellular Location | Nucleus membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).
References
Nusbaum, C., et al. Nature 439(7074):331-335(2006)
Baillat, D., et al. Cell 123(2):265-276(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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