|Application ||WB, IHC-P, FC, E|
|Other Accession||P63090, P63089, NP_002816.1|
|Calculated MW||18942 Da|
|Antigen Region||127-154 aa|
|Other Names||Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1|
|Target/Specificity||This PTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-154 amino acids from the C-terminal region of human PTN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation.|
|Tissue Location||Osteoblast and brain.|
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Provided below are standard protocols that you may find useful for product applications.
PTN ia a heparin binding mitogenic protein. It has neurite extension activity.
Li, F., et al. J. Biol. Chem. 285(36):27673-27685(2010)
Dos Santos, C., et al. Int. J. Cancer 127(5):1038-1051(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Svensson, S.L., et al. J. Biol. Chem. 285(21):16105-16115(2010)
M'Bika, J.P., et al. J. Gen. Virol. 91 (PT 5), 1346-1353 (2010) :
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