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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTN Antibody (C-term)   

PTN Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PTN Antibody (C-term) AP12263b
    PTN Antibody (C-term) (Cat. #AP12263b) western blot analysis in U251,NCI-H460 cell line lysates (35ug/lane).This demonstrates the PTN antibody detected the PTN protein (arrow).
  • IHC-P - PTN Antibody (C-term) AP12263b
    PTN Antibody (C-term) (Cat. #AP12263b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PTN Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - PTN Antibody (C-term) AP12263b
    PTN Antibody (C-term) (Cat. #AP12263b) flow cytometric analysis of U251 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21246
Other Accession P63090, P63089, NP_002816.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 18942 Da
Antigen Region 127-154 aa
Additional Information
Gene ID 5764
Other Names Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1
Target/Specificity This PTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-154 amino acids from the C-terminal region of human PTN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTN
Synonyms HBNF1, NEGF1
Function Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation.
Cellular Location Secreted.
Tissue Location Osteoblast and brain.
Research Areas
Citations (0)

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PTN ia a heparin binding mitogenic protein. It has neurite extension activity.


Li, F., et al. J. Biol. Chem. 285(36):27673-27685(2010)
Dos Santos, C., et al. Int. J. Cancer 127(5):1038-1051(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Svensson, S.L., et al. J. Biol. Chem. 285(21):16105-16115(2010)
M'Bika, J.P., et al. J. Gen. Virol. 91 (PT 5), 1346-1353 (2010) :

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Cat# AP12263b
(40 western blots)
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