|Application ||WB, E|
|Calculated MW||56548 Da|
|Antigen Region||90-117 aa|
|Other Names||Target of EGR1 protein 1, TOE1|
|Target/Specificity||This TOE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the N-terminal region of human TOE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TOE1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.|
|Cellular Location||Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles|
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Provided below are standard protocols that you may find useful for product applications.
TOE1 inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
Olsen, J.V., et al. Cell 127(3):635-648(2006)
De Belle, I., et al. J. Biol. Chem. 278(16):14306-14312(2003)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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