|Application ||WB, E|
|Calculated MW||56548 Da|
|Antigen Region||90-117 aa|
|Other Names||Target of EGR1 protein 1, TOE1|
|Target/Specificity||This TOE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the N-terminal region of human TOE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TOE1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).|
|Cellular Location||Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TOE1 inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
Olsen, J.V., et al. Cell 127(3):635-648(2006)
De Belle, I., et al. J. Biol. Chem. 278(16):14306-14312(2003)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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