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TLE2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TLE2 Antibody (C-term) AP12269b
    TLE2 Antibody (C-term) (Cat. #AP12269b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the TLE2 antibody detected the TLE2 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q04725
Other Accession NP_003251.2, NP_001138234.1, NP_001138233.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 79841 Da
Antigen Region 637-665 aa
Additional Information
Gene ID 7089
Other Names Transducin-like enhancer protein 2, Enhancer of split groucho-like protein 2, ESG2, TLE2
Target/Specificity This TLE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the C-terminal region of human TLE2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTLE2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLE2
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Cellular Location Nucleus.
Tissue Location In all tissues examined, mostly in heart, brain, and muscle
Citations (0)

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Background

TLE2 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

References

He, Z., et al. J. Virol. 84(4):2047-2062(2010)
Arce, L., et al. BMC Cancer 9, 159 (2009) :
Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)
Javed, A., et al. J. Cell. Sci. 113 (PT 12), 2221-2231 (2000) :
Grbavec, D., et al. Biochem. J. 337 (PT 1), 13-17 (1999) :

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$ 295.00
$ 99.00
Cat# AP12269b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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