|Application ||WB, E|
|Other Accession||NP_003251.2, NP_001138234.1, NP_001138233.1|
|Calculated MW||79841 Da|
|Antigen Region||637-665 aa|
|Other Names||Transducin-like enhancer protein 2, Enhancer of split groucho-like protein 2, ESG2, TLE2|
|Target/Specificity||This TLE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the C-terminal region of human TLE2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TLE2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).|
|Tissue Location||In all tissues examined, mostly in heart, brain, and muscle|
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Provided below are standard protocols that you may find useful for product applications.
TLE2 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
He, Z., et al. J. Virol. 84(4):2047-2062(2010)
Arce, L., et al. BMC Cancer 9, 159 (2009) :
Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)
Javed, A., et al. J. Cell. Sci. 113 (PT 12), 2221-2231 (2000) :
Grbavec, D., et al. Biochem. J. 337 (PT 1), 13-17 (1999) :
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