|Application ||WB, E|
|Other Accession||NP_001159490.1, NP_009183.3|
|Calculated MW||73265 Da|
|Antigen Region||34-61 aa|
|Other Names||POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1, RPF-1, POU6F2, RPF1|
|Target/Specificity||This POU6F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human POU6F2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POU6F2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.|
|Tissue Location||Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Di Renzo, F., et al. J. Pediatr. Hematol. Oncol. 28(12):791-797(2006)
Perotti, D., et al. J. Pediatr. Hematol. Oncol. 27(10):521-525(2005)
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