|Application ||WB, IHC-P, E|
|Calculated MW||42508 Da|
|Antigen Region||21-50 aa|
|Other Names||Proteinase-activated receptor 3, PAR-3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2, F2RL2, PAR3|
|Target/Specificity||This F2RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human F2RL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||F2RL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Popovic, M., et al. J. Thromb. Thrombolysis 30(2):164-171(2010)
Van Laer, L., et al. Eur. J. Hum. Genet. 18(6):685-693(2010)
Wysoczynski, M., et al. Mol. Cancer Res. 8(5):677-690(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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