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F2RL2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - F2RL2 Antibody (N-term) AP12288a
    F2RL2 Antibody (N-term) (Cat. #AP12288a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the F2RL2 antibody detected the F2RL2 protein (arrow).
  • IHC-P - F2RL2 Antibody (N-term) AP12288a
    F2RL2 Antibody (N-term) (Cat. #AP12288a)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of F2RL2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00254
Other Accession NP_004092.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42508 Da
Antigen Region 21-50 aa
Additional Information
Gene ID 2151
Other Names Proteinase-activated receptor 3, PAR-3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2, F2RL2, PAR3
Target/Specificity This F2RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human F2RL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsF2RL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name F2RL2
Synonyms PAR3
Function Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut
Research Areas
Citations (0)

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Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Popovic, M., et al. J. Thromb. Thrombolysis 30(2):164-171(2010)
Van Laer, L., et al. Eur. J. Hum. Genet. 18(6):685-693(2010)
Wysoczynski, M., et al. Mol. Cancer Res. 8(5):677-690(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 295.00
$ 99.00
Cat# AP12288a
(40 western blots)
Availability: In Stock
Bulk Size
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