|Application ||WB, E|
|Other Accession||NP_006838.3, NP_001074907.1|
|Calculated MW||49356 Da|
|Antigen Region||44-73 aa|
|Other Names||Leukocyte immunoglobulin-like receptor subfamily B member 4, CD85 antigen-like family member K, Immunoglobulin-like transcript 3, ILT-3, Leukocyte immunoglobulin-like receptor 5, LIR-5, Monocyte inhibitory receptor HM18, CD85k, LILRB4, ILT3, LIR5|
|Target/Specificity||This LILRB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the N-terminal region of human LILRB4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LILRB4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment|
|Tissue Location||Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lu, H.K., et al. J. Biol. Chem. 284(50):34839-34848(2009)
Jones, D.C., et al. Eur. J. Immunol. 39(11):3195-3206(2009)
Brenk, M., et al. J. Immunol. 183(1):145-154(2009)
Brown, D.P., et al. BMC Immunol. 10, 56 (2009) :
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