|Application ||WB, IHC-P, E|
|Calculated MW||27663 Da|
|Antigen Region||229-258 aa|
|Other Names||Follistatin-related protein 3, Follistatin-like protein 3, Follistatin-related gene protein, FSTL3, FLRG|
|Target/Specificity||This FSTL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-258 amino acids from the C-terminal region of human FSTL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FSTL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.|
|Cellular Location||Isoform 1: Secreted.|
|Tissue Location||Expressed in a wide range of tissues.|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.
Miron, P., et al. Prenat. Diagn. 30(3):224-228(2010)
Thadhani, R., et al. Diabetes Care 33(3):664-669(2010)
Bloise, E., et al. BMC Cancer 9, 320 (2009) :
Stamler, R., et al. J. Biol. Chem. 283(47):32831-32838(2008)
Lara-Pezzi, E., et al. Endocrinology 149(11):5822-5827(2008)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.