|Application ||WB, IHC-P, E|
|Other Accession||O35783, Q6XLQ7, O35887, Q3T0K1, NP_001124146.1, NP_001210.1|
|Predicted||Bovine, Mouse, Rabbit, Rat|
|Calculated MW||37107 Da|
|Antigen Region||217-246 aa|
|Other Names||Calumenin, Crocalbin, IEF SSP 9302, CALU|
|Target/Specificity||This CALU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human CALU.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CALU Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).|
|Cellular Location||Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Carlquist, J.F., et al. J. Thromb. Thrombolysis 30(3):358-364(2010)
Hernandez-Romero, D., et al. Ann. Med. 42(6):439-446(2010)
Harada, T., et al. Thromb. Res. 126(3):183-190(2010)
Voora, D., et al. Clin. Pharmacol. Ther. 87(4):445-451(2010)
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