|Application ||WB, IHC-P, E|
|Other Accession||O35783, Q6XLQ7, O35887, Q3T0K1, NP_001124146.1, NP_001210.1|
|Predicted||Bovine, Mouse, Rabbit, Rat|
|Calculated MW||37107 Da|
|Antigen Region||217-246 aa|
|Other Names||Calumenin, Crocalbin, IEF SSP 9302, CALU|
|Target/Specificity||This CALU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human CALU.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CALU Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane. Golgi apparatus. Secreted. Melanosome. Sarcoplasmic reticulum lumen. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|
|Tissue Location||Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Carlquist, J.F., et al. J. Thromb. Thrombolysis 30(3):358-364(2010)
Hernandez-Romero, D., et al. Ann. Med. 42(6):439-446(2010)
Harada, T., et al. Thromb. Res. 126(3):183-190(2010)
Voora, D., et al. Clin. Pharmacol. Ther. 87(4):445-451(2010)
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