|Application ||WB, IHC-P, E|
|Calculated MW||30957 Da|
|Antigen Region||46-75 aa|
|Other Names||Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273, PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2|
|Target/Specificity||This PDCD1LG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the N-terminal region of human PDCD1LG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDCD1LG2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||B7DC, CD273, PDCD1L2, PDL2|
|Function||Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).|
|Cellular Location||Isoform 3: Secreted. Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
PDCD1LG2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Ellis, J.S., et al. J. Immunol. 185(6):3149-3157(2010)
Pena-Cruz, V., et al. J. Invest. Dermatol. 130(9):2222-2230(2010)
Ghiotto, M., et al. Int. Immunol. 22(8):651-660(2010)
Ishizaki, Y., et al. Hum. Genet. (2010) In press :
Kassel, R., et al. Hepatology 50(5):1625-1637(2009)
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