|Application ||WB, IHC-P, E|
|Other Accession||NP_001018238.1, NP_006109.2|
|Calculated MW||31621 Da|
|Antigen Region||161-190 aa|
|Other Names||HCLS1-associated protein X-1, HS1-associating protein X-1, HAX-1, HS1-binding protein 1, HSP1BP-1, HAX1, HS1BP1|
|Target/Specificity||This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the C-terminal region of human HAX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools.|
|Cellular Location||Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Sarcoplasmic reticulum|
|Tissue Location||Ubiquitous. Up-regulated in oral cancers.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Johns, H.L., et al. J. Gen. Virol. 91 (PT 11), 2677-2686 (2010) :
Mekkawy, A.H., et al. Biochem. Biophys. Res. Commun. 399(4):738-743(2010)
Han, J., et al. J. Biol. Chem. 285(29):22461-22472(2010)
Germeshausen, M., et al. Haematologica 95(7):1207-1210(2010)
Burnicka-Turek, O., et al. BMC Cell Biol. 11, 28 (2010) :
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