|Application ||IF, IHC-P, WB, E|
|Other Accession||P54792, Q9WVB9, P51141, NP_004412.2|
|Calculated MW||75187 Da|
|Antigen Region||442-470 aa|
|Other Names||Segment polarity protein dishevelled homolog DVL-1, Dishevelled-1, DSH homolog 1, DVL1|
|Target/Specificity||This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DVL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members.|
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Provided below are standard protocols that you may find useful for product applications.
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Metcalfe, C., et al. J. Cell. Sci. 123 (PT 9), 1588-1599 (2010) :
Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)
Varelas, X., et al. Dev. Cell 18(4):579-591(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) :
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