|Application ||WB, IHC-P, E|
|Calculated MW||103241 Da|
|Antigen Region||409-437 aa|
|Other Names||Alpha-actinin-3, Alpha-actinin skeletal muscle isoform 3, F-actin cross-linking protein, ACTN3|
|Target/Specificity||This ACTN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-437 amino acids from the Central region of human ACTN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.|
|Tissue Location||Expressed only in a subset of type 2 skeletal muscle fibers.|
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Provided below are standard protocols that you may find useful for product applications.
Alpha-actinin is an actin-binding protein with multiple roles in different cell types. This gene expression is limited to skeletal muscle. It is localized to the Z-disc and analogous dense bodies, where it helps to anchor the myofibrillar actin filaments
Rodriguez-Romo, G., et al. Eur. J. Appl. Physiol. 110(6):1099-1106(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Berman, Y., et al. Physiology (Bethesda) 25(4):250-259(2010)
Ruiz, J.R., et al. Scand J Med Sci Sports (2010) In press :
Buxens, A., et al. Scand J Med Sci Sports (2010) In press :
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