|Application ||WB, IHC-P, E|
|Calculated MW||80735 Da|
|Antigen Region||656-684 aa|
|Other Names||Nuclear protein MDM1, MDM1|
|Target/Specificity||This MDM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656-684 amino acids from the C-terminal region of human MDM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MDM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392).|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the centriole lumen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles and is amplified in the mouse transformed 3T3 cell line, and the protein is able to bind to p53. In mouse several transcripts have been described for this gene which result from alternative polyadenylation, splicing and exon usage.
Chang, B., et al. Hum. Mol. Genet. 17(24):3929-3941(2008)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Snyder, L.C., et al. J. Biol. Chem. 263(32):17150-17158(1988)
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