|Application ||WB, IHC-P, E|
|Calculated MW||44099 Da|
|Antigen Region||296-325 aa|
|Other Names||Carbohydrate sulfotransferase 6, 282-, Corneal N-acetylglucosamine-6-O-sulfotransferase, C-GlcNAc6ST, hCGn6ST, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta, GST4-beta, N-acetylglucosamine 6-O-sulfotransferase 5, GlcNAc6ST-5, Gn6st-5, CHST6|
|Target/Specificity||This CHST6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of human CHST6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHST6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD).
Liu, Z., et al. Cornea 29(8):883-888(2010)
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Dang, X., et al. Mol. Vis. 15, 700-705 (2009) :
Birgani, S.A., et al. Mol. Vis. 15, 373-377 (2009) :
Sultana, A., et al. Mol. Vis. 15, 319-325 (2009) :
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