|Application ||WB, IHC-P, E|
|Calculated MW||44099 Da|
|Antigen Region||296-325 aa|
|Other Names||Carbohydrate sulfotransferase 6, 282-, Corneal N-acetylglucosamine-6-O-sulfotransferase, C-GlcNAc6ST, hCGn6ST, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta, GST4-beta, N-acetylglucosamine 6-O-sulfotransferase 5, GlcNAc6ST-5, Gn6st-5, CHST6|
|Target/Specificity||This CHST6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of human CHST6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHST6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD).
Liu, Z., et al. Cornea 29(8):883-888(2010)
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Dang, X., et al. Mol. Vis. 15, 700-705 (2009) :
Birgani, S.A., et al. Mol. Vis. 15, 373-377 (2009) :
Sultana, A., et al. Mol. Vis. 15, 319-325 (2009) :
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