- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Other Accession||P97299, NP_003004.1|
|Calculated MW||33490 Da|
|Antigen Region||263-292 aa|
|Other Names||Secreted frizzled-related protein 2, FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1, SFRP2, FRP2, SARP1|
|Target/Specificity||This SFRP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human SFRP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFRP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.|
|Tissue Location||Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq].
von Marschall, Z., et al. Biochem. Biophys. Res. Commun. 400(3):299-304(2010)
Pehlivan, S., et al. Cancer Genet. Cytogenet. 201(2):128-132(2010)
Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)
Yamamura, S., et al. Mol. Cancer Ther. 9(6):1680-1687(2010)
Forsman, H., et al. BMC Cell Biol. 11, 52 (2010) :
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