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SFRP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96HF1 |
| Other Accession | P97299, NP_003004.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33490 Da |
| Antigen Region | 263-292 aa |
| Gene ID | 6423 |
|---|---|
| Other Names | Secreted frizzled-related protein 2, FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1, SFRP2, FRP2, SARP1 |
| Target/Specificity | This SFRP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human SFRP2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SFRP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SFRP2 |
|---|---|
| Synonyms | FRP2, SARP1 |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq].
References
von Marschall, Z., et al. Biochem. Biophys. Res. Commun. 400(3):299-304(2010)
Pehlivan, S., et al. Cancer Genet. Cytogenet. 201(2):128-132(2010)
Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)
Yamamura, S., et al. Mol. Cancer Ther. 9(6):1680-1687(2010)
Forsman, H., et al. BMC Cell Biol. 11, 52 (2010) :
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