|Application ||WB, FC, E|
|Other Accession||P62914, Q29205, Q9CXW4, Q3T087, NP_000966.2|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||20252 Da|
|Antigen Region||1-30 aa|
|Other Names||60S ribosomal protein L11, CLL-associated antigen KW-12, RPL11|
|Target/Specificity||This RPL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RPL11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPL11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).|
|Cellular Location||Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternative splice variants encoding different isoforms may exist, but they have not been fully characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq].
Sun, X.X., et al. J. Biol. Chem. 285(33):25812-25821(2010)
Konno, Y., et al. Haematologica 95(8):1293-1299(2010)
Dai, M.S., et al. J. Biol. Chem. 285(17):12587-12594(2010)
Holzel, M., et al. J. Biol. Chem. 285(9):6364-6370(2010)
Quarello, P., et al. Haematologica 95(2):206-213(2010)
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